Rejuran Treatment for Large Pores and Acne Scars in Bangkok, Thailand — BAC Clinic 

Rejuran is a type of skin treatment that originated in South Korea. It’s known for its rejuvenating properties, particularly in addressing wide pores, acne scars, and overall skin cell renewal. Rejuran works by injecting polynucleotides (PN) into the skin. These PN molecules are extracted from salmon DNA, and they can help stimulate collagen production and improve skin texture. 

For those looking for a good clinic to undergo Rejuran treatment, BAC (Bangkok Aesthetics Clinic) is recommended. 

BAC (Bangkok Aesthetics Clinic) is known for its expertise in aesthetic procedures and has gained a positive reputation for delivering effective skin treatments, including Rejuran. If you’re interested in addressing issues like wide pores, acne scars, or enhancing overall skin health, BAC Clinic could be a good choice. 

Achieving youthful, radiant, and consistently smooth skin is a desire shared by many. However, we all know that we cannot stop the aging process or the effects that come with age. Each day, we encounter various factors that accelerate these processes, including pollution in our daily lives, different types of stress, and especially sunlight, which is hard to avoid. Even though we may invest in expensive skincare products, take vitamins, use collagen supplements, and exercise for overall health, it often seems insufficient because aging affects deeper layers of the skin. 

Nevertheless, the discovery of Salmon DNA, which can repair skin cells at a deep level, has paved the way for addressing various skin issues at their roots. These issues include challenging skin problems such as severe cystic acne, large pores, and hyperpigmentation issues like melasma, freckles, dark spots, and uneven skin tone. This discovery has led to the development of products that rejuvenate and regenerate skin cells, embracing a profound concept of beauty from within. 

Salmon DNA, also known as DNA shot or Rejuran are skin rejuvenation boosters that stimulate the generation of new skin cells. They are derived from Polyneucleotide (PN) or Salmon DNA, which closely resembles human DNA, making it highly beneficial for the skin. Research has shown that PN is a crucial component in addressing aging skin issues and aiding in wound healing by rejuvenating and repairing from within. It stimulates the proliferation of fibroblast cells, which in turn triggers the production of new collagen to replace damaged cells. Additionally, it helps in stimulating the skin cells to produce hyaluronic acid and collagen, resulting in increased skin moisture and elasticity. Furthermore, it has a regenerative effect that helps reduce fine lines, fill deep furrows, and strengthens the skin barrier, making it thicker and more resilient. Simultaneously, it enhances volume, tightens pores, repairs acne scars, and reduces wrinkles, promoting naturally radiant skin. 

Polyneucleotide (PN) consists of two intertwined strands of polynucleotides, a form of nucleotide subunit extracted from salmon DNA, which closely resembles human DNA, ensuring safety and non-stimulation of the body’s immune response. PN demonstrates long-term effectiveness in generating new skin cells. PN binds to a specific protein called the A2 purine receptor, which is involved in increasing and modifying various functions, including wound healing, reducing inflammation, and repairing damaged cells by stimulating fibroblast proliferation. This leads to collagen and elastin production, proteins that help tighten and firm the skin, visibly reducing wrinkles and tightening pores. 

The action of polyneucleotide in generating new skin cells not only affects the deeper layers of the skin but also includes the epidermis or the outermost layer. This helps strengthen the skin’s protective barrier, resulting in increased moisture and visibly reduced dark spots.

The mechanism of action of Rejuran (Polyneucleotide or PN) when injected into the skin controls the secretion of cytokines that affect the inflammatory process, resulting in anti-inflammatory effects. This leads to the generation of new skin cells by stimulating the secretion of growth factors such as EGF, FGF, IGF, which promote fibroblast activity. 

Additionally, Rejuran induces an angiogenesis effect, improving microcirculation by stimulating rapid formation of capillaries through the secretion of VEGF. This enhances waste removal from the skin and nourishes and maintains skin cells. 

Moreover, Rejuran promotes rapid skin regeneration through the Salvage pathway, a process that utilizes pyrimidine and purine to directly synthesize DNA. This efficient process requires minimal energy and time, facilitating quick skin renewal and repair. 

Research studies have shown that using Polyneucleotide (PN) can accelerate the repair and healing processes in various skin conditions, such as diabetic ulcers, pigmentation issues, and inflammatory skin conditions. These findings demonstrate a new concept in effective skin cell rejuvenation and protection through the use of DNA nucleotides. 

When Rejuran is injected into the dermis, it provides several benefits to the skin: 

• This results in thicker collagen due to an increased number of fibroblast cells responsible for collagen production. Therefore, both the dermis and epidermis become thicker within approximately 28 days, resulting in smoother, denser, and tighter skin. 

• It helps make acne scars appear shallower and tightens pores by repairing and reorganizing collagen that has been damaged by the inflammatory process of acne. Additionally, it assists in skin regeneration, increasing skin thickness by approximately 640 microns within about 4 weeks. 

• It contributes to a more youthful appearance by acting as a rejuvenation booster, improving overall skin elasticity by more than 21.8% compared to before Rejuran injections, which stimulate collagen production. Aging skin tends to lose elasticity over time, but this treatment also reduces wrinkles and helps strengthen the skin structure. 

• Stimulation of Collagen Production: Rejuran stimulates fibroblasts to produce new collagen, which helps improve skin elasticity and firmness. 

• Enhanced Skin Regeneration: It promotes rapid regeneration of skin cells, aiding in the repair of damaged skin and improvement of overall skin texture. 

• Anti-Inflammatory Effects: Rejuran controls the secretion of cytokines, which reduces inflammation in the skin. 

• Improved Microcirculation: Rejuran induces angiogenesis, leading to better microcirculation and nutrient delivery to skin cells. 

• Wound Healing and Repair: Rejuran accelerates the healing process and repairs damaged skin, making it beneficial for conditions like acne scars or pigmentation issues. 

Overall, Rejuran injection contributes to healthier, more rejuvenated skin with improved texture, firmness, and resilience. 

Due to its effectiveness in skin rejuvenation and repairing skin cells at the source within the dermis, Rejuran (รีจูรัน) is suitable for individuals with various skin concerns such as: 

1. Those who want to improve skin elasticity by stimulating natural collagen production. 

2. Individuals seeking rapid skin rejuvenation and repair due to skin aging or damage. 

3. People with acne scars requiring rejuvenation and treatment. 

4. Those desiring smoother, tighter pores. 

5. Individuals with dry, dehydrated skin due to imbalance. 

6. Those looking to add volume and lift to their skin. 

7. Individuals seeking radiant, luminous skin with a Korean glow. 

8. People with oily skin wanting to balance facial oil. 

9. Those aiming to enhance skin’s self-renewal abilities. 

10. Individuals dealing with wrinkles and fine lines. 

*Results may vary for each individual. 

The treatment process involves several steps. Initially, a topical numbing cream is applied and left for approximately 30 minutes. Following this, the procedure is performed by a physician who injects Rejuran (รีจูรัน) beneath the skin’s surface, typically using 2 cc per session across the face. The injection process takes about 15–30 minutes. Afterward, there may be slight swelling at the injection sites, which is addressed with red light therapy for around 15–20 minutes. It’s recommended to avoid washing the face for at least 6 hours following the procedure. Redness and needle marks may gradually diminish over 2–3 days. 

Treatment Frequency: To achieve skin cell rejuvenation, approximately 4 sessions are needed to repair from within. Clear results become more apparent after the 4th to 6th sessions. For optimal results, it’s suggested to undergo 3 treatments every 2–4 weeks. Subsequently, for ongoing maintenance, treatments can be performed every 3–6 months due to the cumulative effect of Rejuran treatment, which improves skin over time with continuous sessions. 

How is Rejuran different from Skin Boosters? 

Although the objectives of using Skin Boosters and Rejuran may seem similar, they differ in their primary components, resulting in distinct functionalities. Skin Boosters primarily contain hyaluronic acid, which hydrates the skin and is injected into the superficial layer to smooth skin and reduce wrinkles. On the other hand, Rejuran Healer, which contains PN as its main component (a DNA Nucleotide), combats skin aging, repairs and rejuvenates damaged skin cells, promoting youthful and healthy skin. It is not used as a dermal filler. In summary, the mechanisms of action of Skin Boosters and Rejuran differ, and combining them can lead to enhanced results in anti-aging, wrinkle reduction, and skin rejuvenation. 

Everything you need to know about Rejuran: 

✅Is Rejuran a biostimulator for volume-depleted acne scars? Expectations vs. Reality: What is Rejuran? Rejuran is a substance derived from Polynucleotide (PN) DNA, which lacks hyaluronic acid components. It is an injectable that aids in skin remodeling or stimulates the body to produce collagen, known as biostimulation. 

How do biostimulators work in tightening and lifting the skin? That is the goal of injection, but results can vary significantly. The primary objective of biostimulation is to continuously activate collagen-producing cells and remain active. Results may differ for each individual. 

Does Rejuran increase skin volume compared to biostimulators (collagen-stimulating fillers) and HA dermal fillers? Rejuran has a lesser impact on increasing skin volume compared to biostimulators (collagen-stimulating fillers) and HA dermal fillers, but it affects the true dermis layer. Its primary role is to stimulate fibroblast cells. In summary, not everyone needs HA dermal fillers for their skin, but everyone can benefit from Polynucleotide/Rejuran biostimulation. 

✅How does Rejuran compare to other collagen stimulating fillers? Traditional collagen stimulating fillers include PLLA (Sculptra) and Radiesse (calcium hydroxyapatite), which stimulate collagen and have different volumizing effects. This may benefit individuals with minimal facial volume or acne scars of volume loss, making them unsuitable for everyone. The immediate effects of collagen-stimulating fillers (biostimulators) come from the gel or carrier. Collagen stimulation from the inflammatory process will occur thereafter, with different collagen results in each individual. 

The best injectables for collagen stimulation without focusing on volume include PCL (polycaprolactone) and polynucleotide (Rejuran). 

✅Therefore, the most cost-effective and biostimulating alternative for individuals with volume-depleted acne scars and the need for biostimulation is: Rejuran/PCL + dermal fillers: Rejuran stimulates collagen production, while dermal fillers increase skin volume, showing immediate results. Rejuran/PCL+ MFR+Filler: This combination strengthens collagen production and increases volume, showing immediate results. 

✅Using Rejuran in conjunction with fillers is a great option for individuals with volume-depleted acne scars and low-level biostimulation needs. This combination enhances skin rejuvenation and reduces long-term costs compared to using biostimulators alone, making it a suitable option for effective and cost-efficient treatments with clear, immediate results, while continuous collagen production continues. 

Using Rejuran in combination with laser treatment is better than using Rejuran as a monotherapy? 

Rejuran plays a crucial role in repairing and rejuvenating skin cells at a cellular level, and it can be used on all skin types. Therefore, when Rejuran is combined with laser treatment, the unique properties of Rejuran enhance and expedite the results. Combining it with laser treatment synergizes the effectiveness. At BAC Clinic, we recommend combining Rejuran with Picosecond Laser and INFINI MFR (Microneedle Fractional RF), as we have found that this combination leads to clearer treatment responses and greater satisfaction among patients. Apart from addressing excess pigmentation, it also helps achieve more even skin tone and smoother skin texture. 

However, the choice of laser treatment to complement Rejuran should be discussed with the treating physician to tailor the treatment specifically to the individual’s concerns and needs.

Can Rejuran be used to treat excess pigmentation, melasma, freckles, or dark spots? 

• Based on research by Dr. S E Change and colleagues, it has been found that Rejuran can effectively reduce pigmentation at a cellular level by controlling the expression of genes involved in pigment production. This demonstrates that besides its known anti-aging effects and collagen-stimulating properties, Rejuran can also address excess pigmentation concerns such as melasma. Therefore, injecting Rejuran is a highly effective option for individuals seeking clear, youthful skin by addressing issues at a cellular level. 

• When used in conjunction with Picosecond Laser, Rejuran’s effectiveness is further enhanced, leading to faster and clearer results without thinning the skin or causing scarring. While the effects of Rejuran may not be immediate, they are worth the wait. Rejuran helps rejuvenate the skin, making it look younger and brighter by repairing skin cells at a deep level. Optimal results can typically be seen after 3–4 sessions spaced 3–4 weeks apart, followed by maintenance treatments every 6–12 months. 

• During treatments at BAC Clinic, we prioritize patient comfort by using local anesthesia, ensuring a virtually painless injection process. Additionally, red light therapy is utilized to reduce swelling and enhance collagen stimulation during each session. 

• Therefore, if you notice signs of skin aging and wish to plan a treatment regimen, you can schedule a consultation directly with our clinic. When choosing a clinic for treatment, ensure that it has experienced physicians capable of designing effective treatment plans and prescribing genuine medications with proper authentication. This comprehensive approach ensures swift problem resolution tailored to each patient’s needs. Always consult with a physician before starting any treatment regimen. 

Should Rejuran be administered manually or using an automatic MESO gun? 

• The process of skin repair and rejuvenation through Rejuran injection involves stimulating fibroblast cells. These fibroblast cells promote collagen and extracellular matrix production, crucial for skin regeneration. The goal of Rejuran injection is to deliver the substance deep into the true dermis layer of the skin. At BAC Clinic, the injection technique is aimed at the Superficial Dermis and Intradermal levels, depending on the treatment objective. Each injection point uses approximately 0.05–0.1 milliliters of Rejuran with a 33G×4mm needle, targeting problem areas such as excess pigmentation, acne, enlarged pores, acne scars, or areas requiring additional volume like the cheeks or chin. 

• The advantage of manual injection lies in the ability to achieve precision, deliver the full dose of Rejuran, and ensure accurate targeting of the desired skin layer for optimal results. This differs from using a Meso gun, where the medication delivery is controlled by the instrument’s needles and pressure, often leading to subcutaneous delivery rather than true dermal penetration. Additionally, Meso gun usage may cause discomfort and more noticeable marks compared to manual injection due to the mechanical forces involved. 

• Choosing manual injection is ideal for those seeking targeted and detailed treatment without relying solely on mechanical delivery. Therefore, for the best outcomes with Rejuran, manual injection remains the preferred method to ensure the medication reaches its target cells effectively, allowing the physician to design a precise and tailored treatment plan. 

Rejuran  

Helps thinning skin become younger and healthier with ten different effects that make you look ten years younger! 

Rejuran  is a skin-healing treatment, as the name suggests. In other words, it contains a skin healing solution with skin care and anti-aging properties. The primary component of Rejuran Healer is PN (Polynucleotide), a bio-composite with deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) biological functions (RNA). This ingredient is completely safe and has no negative side effects. It is an active tissue regeneration material that promotes cell tissue self-renewal and can be used for tissue regeneration as well as wound healing. Furthermore, increasing the thickness and density of the dermis, it promotes essential skin health by controlling oil and moisture balance, shrinking pores, improving sensitive skin, and restoring damaged skin tissue. 

What is the difference between Salmon Injection (PDRN)? 

Salmon injection, like Rejuran Healer, is a skin regenerating/skin boosting procedure. Because they contain similar ingredients, Rejuran Healer and PDRN accompany each other. The main ingredient of salmon injection, PDRN, is a bio regeneration material similar to PN that aids in rapid skin regeneration by utilizing cell tissues’ self-renewal ability. Rejuran Healer’s PN is a high molecular substance extracted from the testis of DNA, whereas PDRN is a standardized ingredient in a specific size. 

What are the side effects or complications of the procedure? 

Rejuran Healer is a procedure with no side effects and a safe ingredient used in various major surgeries as a tissue regeneration activating substance with demonstrated stability. As a result, skin that has been damaged due to laser management is treatable, such as thin and sensitive skin and skin with severe seborrheic dermatitis. Skin that is imbalanced and unable to receive laser treatments can be treated. Because the procedure involves injections all over the face, redness, bruising, and temporary swelling may occur for approximately 1 week after the procedure. You may experience dryness for 1–2 weeks following the procedure, which is normal because it is a natural phenomenon in which collagen is activated in the dermis of the skin to balance damaged skin, so please moisturize adequately. 

Doctors frequently use Rejuran Healer treatment to treat the following conditions, often with excellent results, due to its natural skin-rejuvenating and healing effects: 

• Dark circles under the eyes 

• Pore enlargement 

• Fine lines and wrinkles 

• Scars from acne 

• Skin sagging 

• Skin that is dehydrated 

How frequently and how many times should I receive Rejuran Healer? 

Each Rejuran Healer skinboosters treatment uses 1 syringe (2ml) of Rejuran Healer for a full face treatment. 3–4 treatments spaced 3–4 weeks apart are recommended. A single treatment is then repeated once every 6–12 months as maintenance to combat the effects of aging. 

Is it OK to combine Rejuran healer and Chanel injection? 

1. Rejuran has the ability to regenerate fresh skin. (Regeneration) or rejuvenation healing at cellular level. As a result, when combined with Chanel (versions 1 & 2), the main ingredient is HA or hyaluronic acid. As a result, the skin is more hydrated, and the effectiveness of producing new skin cells at the foundation level is improved. It also moisturizes the skin at the same time. 

2. A study discovered that PN (Polyneucleotide; Rejuran) and HA when administered together will maximize (Synergy effect) by increasing the percentage of Dermal fibroblasts or fibroblasts in the dermis layer .Hyaluronic provides the aid for fibroblast proliferation. It also increases the viability of fibroblasts, which are cells that play a crucial part in the production of new collagen for the skin. 

3. The injection is thus appropriate for individuals who desire to boost skin strength by enhancing the ability to generate new skin cells (skin regeneration ability) and improving skin moisture retention. 

4. Combination injection It will aid in the most effective use of Rejuran. Rejuran’s efficacy improves with dose (Dose — dependant), making it ideal for those who want immediate results from a single injection. 

5. Combination injection is appropriate for people who require immediate outcomes. as well as elderly patients Individuals over the age of 40 who seek to minimize wrinkles.This is due to aging and dry, dehydrated skin reducing the ability to generate new skin cells. 

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